Moses - Imprinting Technology and Modeling

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Diese Modulbeschreibung gilt nicht im aktuellen Semester.

Die Modulbeschreibung gilt nur für den Zeitraum SS 2017 - SS 2017.

Module / Version:
#20501 / #1

Validity:
SS 2017 - SS 2017

Default display language:
English

Module title:
Imprinting Technology and Modeling

Credits:
6

Responsible person:
Schomäcker, Reinhard

Grading:
benotet

Type of exam:
Portfolioprüfung

Zugehörigkeit

Faculty:
Fakultät II

Institute:
Institut für Chemie

Area of expertise:
No information

Prüfungsausschuss:
No information

Kontakt

Office:
TC 8

Contact person:
Beuster, Frank

E-mail address:
schomaecker@tu-berlin.de

Website:

http://www.chemie.tu-berlin.de/dr_zeynep_altintas/home/

Learning Outcomes

After this course, the student is able to: • Discuss the motivation, merits, and challenges in the field of Molecularly Imprinted Polymers • Describe covalent, semi-covalent and non-covalent imprinting approaches with their advantages and limitations • Determine various production methods of MIPs such as monolith, precipitation, solid phase, covalent attachment, metal-coordination • Discuss the availability and importance of MIPs as recognition elements in many fields from environmental toxicology to medical diagnostics • Aware of major differences between small and macromolecule imprinting as well as difference between chemical compound and biological target (protein, bacteria, virus, etc) imprinting • Describe application areas of MIPs, particularly in the areas of biosensors, solid phase extraction, membrane seperation technology as well as in catalytic synthesis and degrations, drug delivery and release. • Discuss the impact and motivation of computational programs in molecular imprinting technology • Describe the workflow of computational simulations throughout molecular modelling investigations of targeted compounds (templates) from structure preparation to molecular dynamics evaluations and finding best possible monomer/s and/or crosslinkers for imprinting recipes. • Be familiar to SYBLY and VMD/NAMD computational programs for virtual screening of a compound of interest to be imprinted.

Content

1. Molecular Imprinting Technology and molecularly imprinted polymers (MIPs) 2. Covalent, semi-covalent and non-covalent imprinting approaches 3. Production methods of MIPs such as monolith, precipitation, solid phase, covalent attachment, metal-coordination 4. MIPs as recognition elements in many fields from environmental toxicology to medical diagnostics 5. Major differences between small and large target imprinting. 6. Application areas of MIPs 7. Use of molecular modelling approaches to improve the success of MIPs while decreasing the required cost and time 8. SYBLY and VMD/NAMD computational programs for virtual screening of a compound of interest to be imprinted.

Module Components

Pflichtgruppe:

All Courses are mandatory.

Course Name	Type	Number	Cycle	Language	SWS	VZ
Molecular Imprinting Technology and Molecular Modeling	SEM	L9223	WiSe/SoSe	English	2
Molecular Imprinting Technology and Molecular Modeling	VL	L 9222	WiSe/SoSe	English	2

Workload and Credit Points

Molecular Imprinting Technology and Molecular Modeling (SEM):

Workload description	Multiplier	Hours	Total
Präsenzzeit	15.0	2.0h	30.0h
Prüfungsvorbereitung und Prüfung	15.0	2.0h	30.0h
Vor-/Nachbereitung	15.0	2.0h	30.0h
			90.0h(~3 LP)

Molecular Imprinting Technology and Molecular Modeling (VL):

Workload description	Multiplier	Hours	Total
Präsenzzeit	15.0	2.0h	30.0h
Prüfungsvorbereitung und Prüfung	15.0	2.0h	30.0h
Vor-/Nachbereitung	15.0	2.0h	30.0h
			90.0h(~3 LP)

The Workload of the module sums up to 180.0 Hours. Therefore the module contains 6 Credits.

Description of Teaching and Learning Methods

Vorlesung (VL): Vermittlung des Stoffes durch eine Vorlesung (Kern des Moduls) Seminar (SE): Vertiefung des Vorlesungsstoffes anhand ausgewählter Themen. Includes a laboratory tour at Fraunhofer Institute for Applied Polymer Research.

Requirements for participation and examination

Desirable prerequisites for participation in the courses:

Empfohlen: Modul „Chemie der Polymere“ or „Organische Chemie“

Mandatory requirements for the module test application:

This module has no requirements.

Module completion

Grading

graded

Type of exam

Portfolio examination

Type of portfolio examination

100 Punkte insgesamt

Language

English

Test elements

Name	Points	Categorie	Duration/Extent
Schriftliche Prüfung über den Inhalt der Vorlesung und Übung	50	written	89 min
Schriftliche Ausarbeitung	50	written	ca. 10 Seiten

Grading scale

This exam uses its own grading scale (see test description).

Test description (Module completion)

No information

Duration of the Module

The following number of semesters is estimated for taking and completing the module:
1 Semester.

This module may be commenced in the following semesters:
Winter- und Sommersemester.

Maximum Number of Participants

This module is not limited to a number of students.

Registration Procedures

Die Anmeldung zur Modulprüfung erfolgt über die zentrale Online-Prüfungsverwaltung.

Recommended literature
B. Sellergren, Molecularly Imprinted Polymers, 1. Auflage, ELSEVIER, Amsterdam, 2001.
M. Yan, O. Ramstrom, Molecularly Imprinted Materials: Science and Technology, CRC Press, 2004.
Z. Altintas, Analytical chemistry 87 (13), 6801-6807, 2015; Sensors and Actuators B: Chemical 224, 726-737, 2016; Biosensors and Bioelectronics 74, 996-1004, 2015; Molecular imprinting technology in advanced biosensors for diagnostics 1-30, Nova Science Publishers, 2015; Analytica Chimica Acta doi:10.1016/j.aca.2016.06.013, 2016; Chemical Engineering Journal 300, 358-366, 2016.

Assigned Degree Programs

This module is not used in any degree program.

Students of other degrees can participate in this module without capacity testing.

Wahlmodul für Material Science, Chemical Engineering, Chemistry, Process Engineering. Master students are encouraged.

Miscellaneous

Ansprechpartnerin/contact: Dr. Zeynep Altintas, zeynep.altintas@tu-berlin.de, (Tel. 23670) This course will be taught in English.

Imprinting Technology and Modeling